新葡萄京娱乐场app-澳门葡萄京官方老平台

姓 名: 窦君
性 别:
职 务:
职 称: 副研究员(自然科学)
通讯地址: 乌鲁木齐市北京南路40号附1号
邮政编码: 830011
电子邮件: doujun@ms.xjb.ac.cn

简历:

  汉族,博士。主要研究方向为药理学和民族医药的研究与开发。现任新葡萄京娱乐场app-澳门葡萄京官方老平台副研究员(项目聘用)。近年来,主持或参与国家、省部级课题6项。曾获军队科技进步二等奖1项;新疆维吾尔自治区科技进步三等奖1项,新疆第六届青年学术年会优秀学术论文二等奖1项;新疆维吾尔自治区自然科学优秀学术论文三等奖1项;发明专利4项;

主要研究领域以及成就:

  维吾尔药治疗糖尿病、白癜风、自身免疫性疾病等的分子机制

代表性文章:

  (1) Chen Z, Wang L, Yao D, Yang T, Cao WM, Dou J, Pang JC, Guan S, Zhang H, Yu Y, Zhao Y, Wang Y, Xu X, Shi Y, Patel R, Zhang H, Vasudevan SA, Liu S, Yang J, Nuchtern JG. Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis. Sci Rep. 2016 Dec 19;6:38011. doi: 10.1038/srep38011.

  (2) Niu C, Pang GX, Li G, Dou J, Nie LF, Himit H, Kabas M, Aisa HA. Synthesis and biological evaluation of furocoumarin derivatives on melanin synthesis in murine B16 cells for the treatment of vitiligo. Bioorg Med Chem. 2016 Nov 15;24(22):5960-5968. doi: 10.1016/j.bmc.2016.09.056. Epub 2016 Sep 23

  (3) Niu C, Yin L, Nie LF, Dou J, Zhao JY, Li G, Aisa HA. Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo. Bioorg Med Chem. 2016 Nov 1;24(21):5440-5448. doi: 10.1016/j.bmc.2016.08.066. Epub 2016 Sep 1.

  (4) Wang H, Yu Y, Jiang Z, Cao WM, Wang Z, Dou J, Zhao Y, Cui Y, Zhang H. Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis. Sci Rep. 2016 May 24;6:26456. doi: 10.1038/srep26456.

  (5) Zhang H, Dou J, Yu Y, Zhao Y, Fan Y, Cheng J, Xu X, Liu W, Guan S, Chen Z, shi Y, Patel R, Vasudevan SA, Zage PE, Zhang H, Nuchtern JG, Kim ES, Fu S, Yang J. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling. Apoptosis. 2015, 20(1): 50-62.

  (6) Cheng J, Fan Y-H, Xu X, Zhang H, Dou J, Tang Y, Zhong X, Rojas Y, Yu Y, Zhao Y Vasudevan, S A, Zhang H, Nuchtern J G, Kim E S, Chen X, Lu F, Yang J. A small molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death and Disease (2014) 5, e1079; doi:10.1038/cddis.2014.54

  (7) Fan YH, Cheng J, Vasudevan S A, Dou J, Zhang H, Pate R H, Ma I T, Rojas Y, Zhao Y, Yu Y, Zhang H, Shohet J M, Nuchtern J G, Kim E S, Yang J. USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death and Disease (2013) 4, e867; doi:10.1038/cddis.2013.400.

  (8) Zhao Y, Dou J, Wu T, Aisa HA. Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam. Molecules, 2013, 18(1): 951-962.

  (9) Lin J, Dou J, Xu J, Aisa HA. Chemical Composition, Antimicrobial and Antitumor Activitiesof the Essential Oils and Crude Extracts of Euphorbia macrorrhiza. Molecules, 2012, 17: 5030-5039.

代表性专利:

  1. 贺耀武,曹玲华,窦君,阿吉艾克拜尔·艾萨,芳基四唑糖基衍生物及其制备方法和用途, 2013. 04. 03, 中国,CN101723995B

  2. 阿吉艾克拜尔·艾萨;程珍;阿布力米提·伊力;吕俏莹;高彦华;窦君,一种鹰嘴豆豆芽有效成分的纯化方法, 2012.04.18,中国,CN102000138B,

  3. 阿吉艾克拜尔·艾萨; 阿布力米提·伊力;程珍;毛人杰;窦君,鹰嘴豆豆芽有效部位及其制备方法和应用, 2012.04.18,中国,CN102068486B

  4. 阿吉艾克拜尔·艾萨;程珍;吕俏莹;阿布力米提·伊力;窦君,一种鹰嘴豆总皂苷的制备方法, 2011.09.07,中国,CN101991635B

研究领域:

药理学与民族医药的研发

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